I believe it is possible. San Francisco Bay used to be a river many, many years ago. The Farallon Islands mark the area where there used to be a waterfall at the end of that river. As ocean levels rose after the last ice age, the river disappeared and the area that is now the bay, filled with salt water. The headlands you see in the foreground are caused by seismic movement over many years also. These forces are more powerful than anything built by humans.
If the San Andreas Fault moves like it did in 1906, I believe this bridge will suffer major damage and possibly block the entry into San Francisco Bay, thus preventing ships from bringing needed supplies into the Port of Oakland. This would cut off many goods from there normal connection with trucking lines that carry them to other places in the country and the state. This incident would also cut off some goods and supplies from leaving the port for other places in the world.
More information can be found at Preparing With Dave
When it comes to disaster, there are simple things you can do to make yourself safer. The information on this page is designed as a step-by-step guide to give you details on what to do before, during, and after an earthquake. Start with the simple tips within each step so that you can build on your accomplishments.
An example of this in Step 1 is moving heavy, unsecured objects from top shelves onto lower ones. This will only take minutes to complete and you are safer from that hazard!
You can find more information at Earthquake Country